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A Dynamic Stress Model Explains the Delayed Drug Effect in Artemisinin Treatment of Plasmodium falciparum

Abstract:

Artemisinin resistance constitutes a major threat to the continued success of control programs for malaria, particularly in light of developing resistance to partner drugs. Improving our understanding of how artemisinin-based drugs act and how resistance manifests is essential for the optimization of dosing regimens and the development of strategies to prolong the life span of current first-line treatment options. Recent short-drug-pulse in vitro experiments have shown that the parasite killi...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1128/aac.00618-17

Authors


Zaloumis, S More by this author
Dogovski, C More by this author
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Wellcome Trust More from this funder
Publisher:
American Society for Microbiology Publisher's website
Journal:
Antimicrobial agents and chemotherapy Journal website
Volume:
61
Issue:
12
Pages:
e00618-17
Publication date:
2017-10-09
Acceptance date:
2017-09-28
DOI:
ISSN:
0066-4804 and 1098-6596
Pubs id:
pubs:737163
URN:
uri:e630bdf8-707d-4dc3-96c4-0e958760b3ee
UUID:
uuid:e630bdf8-707d-4dc3-96c4-0e958760b3ee
Local pid:
pubs:737163

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