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Cutting edge: activation by innate cytokines or microbial antigens can cause arrest of natural killer T cell patrolling of liver sinusoids.

Abstract:

Natural killer T (NKT) cells are innate-like lymphocytes that rapidly secrete large amounts of effector cytokines upon activation. Recognition of alpha-linked glycolipids presented by CD1d leads to the production of IL-4, IFN-gamma, or both, while direct activation by the synergistic action of IL-12 and IL-18 leads to IFN-gamma production only. We previously reported that in vitro cultured dendritic cells can modulate NKT cell activation and, using intravital fluorescence laser scanning micro...

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Publisher copy:
10.4049/jimmunol.180.4.2024

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Journal:
Journal of immunology (Baltimore, Md. : 1950)
Volume:
180
Issue:
4
Pages:
2024-2028
Publication date:
2008-02-05
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
URN:
uuid:e6277e01-73d2-48c9-9a22-fde6be283523
Source identifiers:
426321
Local pid:
pubs:426321

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