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Journal article

Regulatory polymorphisms underlying complex disease traits.

Abstract:

There is growing evidence that genetic variation plays an important role in the determination of individual susceptibility to complex disease traits. In contrast to coding sequence polymorphisms, where the consequences of non-synonymous variation may be resolved at the level of the protein phenotype, defining specific functional regulatory polymorphisms has proved problematic. This has arisen for a number of reasons, including difficulties with fine mapping due to linkage disequilibrium, toge...

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Publication status:
Published

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Publisher copy:
10.1007/s00109-004-0603-7

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, WTC Human Genetics
Journal:
Journal of molecular medicine (Berlin, Germany)
Volume:
83
Issue:
2
Pages:
97-109
Publication date:
2005-02-05
DOI:
EISSN:
1432-1440
ISSN:
0946-2716
URN:
uuid:e61754b1-cae4-4bca-8511-c96693af2278
Source identifiers:
23882
Local pid:
pubs:23882

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