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Comparison of guinea-pig ventricular myocytes and dog Purkinje fibres for in vitro assessment of drug-induced delayed repolarization.

Abstract:

INTRODUCTION: QT interval prolongation and Torsade de Pointes (TdP) arrhythmias are recognised as a potential risk with many drugs, most of which delay cardiac repolarization by inhibiting the rapidly activating K(+) current (I(Kr)). The objective of this study was to compare the effects of compounds on cardiac action potentials recorded from guinea-pig ventricular myocytes and dog Purkinje fibres. METHODS AND RESULTS: Effects of dofetilide, sotalol, cisapride, terfenadine, haloperidol and s...

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Publisher copy:
10.1016/j.vascn.2007.04.005

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Pharmacology, BHF Centre of Research Excellence
Wilson, CM More by this author
Graham, SG More by this author
Bryant, SM More by this author
Journal:
Journal of pharmacological and toxicological methods
Volume:
56
Issue:
2
Pages:
171-185
Publication date:
2007
DOI:
EISSN:
1873-488X
ISSN:
1056-8719
URN:
uuid:e615418d-d380-4603-9d12-0bbb4905038e
Source identifiers:
106183
Local pid:
pubs:106183

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