- Abstract:
-
INTRODUCTION: QT interval prolongation and Torsade de Pointes (TdP) arrhythmias are recognised as a potential risk with many drugs, most of which delay cardiac repolarization by inhibiting the rapidly activating K(+) current (I(Kr)). The objective of this study was to compare the effects of compounds on cardiac action potentials recorded from guinea-pig ventricular myocytes and dog Purkinje fibres. METHODS AND RESULTS: Effects of dofetilide, sotalol, cisapride, terfenadine, haloperidol and s...
Expand abstract - Publisher copy:
- 10.1016/j.vascn.2007.04.005
-
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- Journal:
- Journal of pharmacological and toxicological methods
- Volume:
- 56
- Issue:
- 2
- Pages:
- 171-185
- Publication date:
- 2007
- DOI:
- EISSN:
-
1873-488X
- ISSN:
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1056-8719
- URN:
-
uuid:e615418d-d380-4603-9d12-0bbb4905038e
- Source identifiers:
-
106183
- Local pid:
- pubs:106183
- Language:
- English
- Keywords:
- Copyright date:
- 2007
Journal article
Comparison of guinea-pig ventricular myocytes and dog Purkinje fibres for in vitro assessment of drug-induced delayed repolarization.
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