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A choreography of nicotinic receptors directs the dopamine neuron routine.

Abstract:
Modulation of the mesocorticolimbic dopamine system by nicotinic acetylcholine receptors (nAChRs) is thought to play an important role in both health and addiction. However, a clear understanding of how these receptors regulate in vivo firing activity has been elusive. In this issue of Neuron, Mameli-Engvall and colleagues report an impressive and thought-provoking series of in vivo experiments combining single-unit recordings from dopamine neurons with nAChR subunit deletions and region-specific lentiviral subunit re-expression.
Publication status:
Published

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Authors


Ungless, MA More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Journal:
Neuron
Volume:
50
Issue:
6
Pages:
815-816
Publication date:
2006-06-05
DOI:
EISSN:
1097-4199
ISSN:
0896-6273
URN:
uuid:e605178e-d2ac-4928-8feb-df4ff30144f1
Source identifiers:
113718
Local pid:
pubs:113718

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