Kinetics of reduction of tyrosine phenoxyl radicals by glutathione.
Modification of tyrosine (TyrOH) is used as a marker of oxidative and nitrosative stress. 3,3'-Dityrosine formation, in particular, reflects oxidative damage and results from the combination of two tyrosyl phenoxyl radicals (TyrO·). This reaction is in competition with reductive processes in the cell which 'repair' tyrosyl radicals: possible reductants include thiols and ascorbate. In this study, a rate constant of 2 x 10⁶ M⁻¹ s⁻¹ was estimated for the reaction between tyrosyl radicals and gl...Expand abstract
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