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Kinetics of reduction of tyrosine phenoxyl radicals by glutathione.

Abstract:

Modification of tyrosine (TyrOH) is used as a marker of oxidative and nitrosative stress. 3,3'-Dityrosine formation, in particular, reflects oxidative damage and results from the combination of two tyrosyl phenoxyl radicals (TyrO·). This reaction is in competition with reductive processes in the cell which 'repair' tyrosyl radicals: possible reductants include thiols and ascorbate. In this study, a rate constant of 2 x 10⁶ M⁻¹ s⁻¹ was estimated for the reaction between tyrosyl radicals and gl...

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Publisher copy:
10.1016/j.abb.2010.12.006

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
Trujillo, M More by this author
Bartesaghi, S More by this author
Wardman, P More by this author
Journal:
Archives of biochemistry and biophysics
Volume:
506
Issue:
2
Pages:
242-249
Publication date:
2011-02-05
DOI:
EISSN:
1096-0384
ISSN:
0003-9861
URN:
uuid:e5f5f83c-05d7-462a-a0d0-39c2705a4894
Source identifiers:
271116
Local pid:
pubs:271116

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