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Linkage analysis of extremely discordant and concordant sibling pairs identifies quantitative-trait loci that influence variation in the human personality trait neuroticism.

Abstract:

Several theoretical studies have suggested that large samples of randomly ascertained siblings can be used to ascertain phenotypically extreme individuals and thereby increase power to detect genetic linkage in complex traits. Here, we report a genetic linkage scan using extremely discordant and concordant sibling pairs, selected from 34,580 sibling pairs in the southwest of England who completed a personality questionnaire. We performed a genomewide scan for quantitative-trait loci (QTLs) th...

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Publication status:
Published

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Publisher copy:
10.1086/374178

Authors


Fullerton, J More by this author
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Journal:
American journal of human genetics
Volume:
72
Issue:
4
Pages:
879-890
Publication date:
2003-04-05
DOI:
EISSN:
1537-6605
ISSN:
0002-9297
URN:
uuid:e5e618b1-e3d2-4bdb-8ac6-b86b17752dd0
Source identifiers:
32324
Local pid:
pubs:32324

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