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Journal article

Sustained dysfunction of antiviral CD8+ T lymphocytes after infection with hepatitis C virus.

Abstract:

Hepatitis C virus (HCV) sets up persistent infection in the majority of those exposed. It is likely that, as with other persistent viral infections, the efficacy of T-lymphocyte responses influences long-term outcome. However, little is known about the functional capacity of HCV-specific T-lymphocyte responses induced after acute infection. We investigated this by using major histocompatibility complex class I-peptide tetrameric complexes (tetramers), which allow direct detection of specific ...

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Publication status:
Published

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Journal:
Journal of virology
Volume:
75
Issue:
12
Pages:
5550-5558
Publication date:
2001-06-05
DOI:
EISSN:
1098-5514
ISSN:
0022-538X
URN:
uuid:e5dfa12a-86ef-4f5b-bee1-957d8f49d2e2
Source identifiers:
11326
Local pid:
pubs:11326

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