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Cellular effects of deoxynojirimycin analogues: inhibition of N-linked oligosaccharide processing and generation of free glucosylated oligosaccharides.

Abstract:

In the accompanying paper [Mellor, Neville, Harvey, Platt, Dwek and Butters (2004) Biochem. J. 381, 861-866] we treated HL60 cells with N-alk(en)yl-deoxynojirimycin (DNJ) compounds to inhibit glucosphingolipid (GSL) biosynthesis and identified a number of non-GSL-derived, small, free oligosaccharides (FOS) most likely produced due to inhibition of the oligosaccharide-processing enzymes a-glucosidases I and II. When HL60 cells were treated with concentrations of N-alk(en)ylated DNJ analogues t...

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Publication status:
Published

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Publisher copy:
10.1042/BJ20031824

Authors


Mellor, HR More by this author
Neville, DC More by this author
Harvey, DJ More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pharmacology
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Journal:
The Biochemical journal
Volume:
381
Issue:
Pt 3
Pages:
867-875
Publication date:
2004-08-05
DOI:
EISSN:
1470-8728
ISSN:
0264-6021
URN:
uuid:e5ccdd1f-7e96-4a97-bb8d-c49c17d3b3e9
Source identifiers:
101085
Local pid:
pubs:101085

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