Three-year follow-up of the Oxford Cholesterol Study: assessment of the efficacy and safety of simvastatin in preparation for a large mortality study.

Journal article

We report the results of a randomized single-centre study designed to assess the effects of simvastatin on blood lipids, blood biochemistry, haematology and other measures of safety and tolerability in preparation for a large-scale multicentre mortality study. Six hundred and twenty-one individuals considered to be at increased risk of coronary heart disease were randomized, following a 2-month placebo 'run-in' period, to receive 40 mg daily simvastatin, 20 mg daily simvastatin or matching pl...

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Authors: Keech, A; Collins, R; MacMahon, S; Armitage, J; Lawson, A

• Publication status: Published
• Journal: European heart journal
• Volume: 15
• Issue: 2
• Pages: 255-269
• Publication date: 1994-02-01
• EISSN: 1522-9645
• ISSN: 0195-668X
• Language: English
• Keywords: Liver Function Tests; Adult; Simvastatin; Treatment Outcome; Aged; Lovastatin; Myocardial Infarction; Lipids; Female; Male; Anticholesteremic Agents; Follow-Up Studies; Survival Analysis; Humans; Coronary Disease; Hypercholesterolemia; Prospective Studies; Middle Aged; Cholesterol; Survival Rate