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Three-year follow-up of the Oxford Cholesterol Study: assessment of the efficacy and safety of simvastatin in preparation for a large mortality study.

Abstract:

We report the results of a randomized single-centre study designed to assess the effects of simvastatin on blood lipids, blood biochemistry, haematology and other measures of safety and tolerability in preparation for a large-scale multicentre mortality study. Six hundred and twenty-one individuals considered to be at increased risk of coronary heart disease were randomized, following a 2-month placebo 'run-in' period, to receive 40 mg daily simvastatin, 20 mg daily simvastatin or matching pl...

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Publication status:
Published

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Authors


Collins, R More by this author
MacMahon, S More by this author
Armitage, J More by this author
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Journal:
European heart journal
Volume:
15
Issue:
2
Pages:
255-269
Publication date:
1994-02-05
EISSN:
1522-9645
ISSN:
0195-668X
URN:
uuid:e5c872e7-e879-4409-adf9-7f8463f22aec
Source identifiers:
44389
Local pid:
pubs:44389

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