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Social adversity, the serotonin transporter (5-HTTLPR) polymorphism and major depressive disorder.

Abstract:

BACKGROUND: Recent evidence has suggested that the short allele of the serotonin transporter (5-HTT) gene-linked polymorphic region (5-HTTLPR of the human serotonin gene [SLC6A4]) is associated with increased risk of depressive disorder but only among individuals exposed to social adversity. We report an investigation designed to replicate this finding. METHODS: Data were available from a non-clinical sample of 4,175 adult men and women, ages 41-80 years, selected from participants in the Eur...

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Publication status:
Published

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Authors


Surtees, PG More by this author
Wainwright, NW More by this author
Willis-Owen, SA More by this author
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Journal:
Biological psychiatry
Volume:
59
Issue:
3
Pages:
224-229
Publication date:
2006-02-05
DOI:
EISSN:
1873-2402
ISSN:
0006-3223
URN:
uuid:e5c7fd7e-6d84-41d3-9eb1-dcf3e6513722
Source identifiers:
39856
Local pid:
pubs:39856

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