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Thesis

Structural and functional studies on human PHD finger protein 2

Abstract:

Histone lysine methylation is an important post-translational modification (PTM) that can regulate gene expression in eukaryotic genomes. Histone methylation states are dynamically altered by the activity of methyl-transferases and demethylases, including the Jumonji C-domain-containing histone demethylases (JHDMs). The JHDM enzymes are members of the Fe(II) and 2-oxoglutarate (2OG) dependent dioxygenases superfamily, which utilise Fe(II) as a cofactor, and 2OG and oxygen as co-substrates ...

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Institution:
University of Oxford
Research group:
Professor Christopher Schofield
Oxford college:
Wolfson College
Department:
Mathematical,Physical & Life Sciences Division - Chemistry - Chemical Biology

Contributors

Role:
Supervisor
Publication date:
2014
Type of award:
MSc by Research
Level of award:
Masters
Awarding institution:
Oxford University, UK
URN:
uuid:e5c1c96a-8642-4fcd-832b-5d47448a3ecd
Local pid:
ora:9758
Language:
English
Keywords:
Subjects:

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