- Abstract:
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BACKGROUND: Adjuvants enhance or modify an immune response that is made to an antigen. An antagonist of the chemokine CCR4 receptor can display adjuvant-like properties by diminishing the ability of CD4+CD25+ regulatory T cells (Tregs) to down-regulate immune responses. METHODOLOGY: Here, we have used protein modelling to create a plausible chemokine receptor model with the aim of using virtual screening to identify potential small molecule chemokine antagonists. A combination of homology mod...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Files:
-
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(pdf, 546.3KB)
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- Publisher copy:
- 10.1371/journal.pone.0008084
-
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- Publisher:
- Public Library of Science Publisher's website
- Journal:
- PloS One Journal website
- Volume:
- 4
- Issue:
- 11
- Pages:
- Article: e8084
- Publication date:
- 2009-01-01
- DOI:
- EISSN:
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1932-6203
- ISSN:
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1932-6203
- URN:
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uuid:e5b79d00-7dc1-48b4-a7a6-1afe3e36108f
- Source identifiers:
-
35017
- Local pid:
- pubs:35017
- Language:
- English
- Keywords:
- Copyright holder:
- Davies et al.
- Copyright date:
- 2009
- Notes:
- Copyright 2009 Davies et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Journal article
Toward the discovery of vaccine adjuvants: coupling in silico screening and in vitro analysis of antagonist binding to human and mouse CCR4 receptors.
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Edward Jenner Institute for Vaccine Research
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Wellcome Trust
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