Journal article
Toward the discovery of vaccine adjuvants: coupling in silico screening and in vitro analysis of antagonist binding to human and mouse CCR4 receptors.
- Abstract:
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BACKGROUND: Adjuvants enhance or modify an immune response that is made to an antigen. An antagonist of the chemokine CCR4 receptor can display adjuvant-like properties by diminishing the ability of CD4+CD25+ regulatory T cells (Tregs) to down-regulate immune responses. METHODOLOGY: Here, we have used protein modelling to create a plausible chemokine receptor model with the aim of using virtual screening to identify potential small molecule chemokine antagonists. A combination of homology mod...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 546.3KB)
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- Publisher copy:
- 10.1371/journal.pone.0008084
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Authors
Funding
Wellcome Trust
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Edward Jenner Institute for Vaccine Research
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Bibliographic Details
- Publisher:
- Public Library of Science Publisher's website
- Journal:
- PloS One Journal website
- Volume:
- 4
- Issue:
- 11
- Article number:
- e8084
- Publication date:
- 2009-01-01
- DOI:
- EISSN:
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1932-6203
- ISSN:
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1932-6203
- Source identifiers:
-
35017
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:35017
- UUID:
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uuid:e5b79d00-7dc1-48b4-a7a6-1afe3e36108f
- Local pid:
- pubs:35017
- Deposit date:
- 2012-12-19
Terms of use
- Copyright holder:
- Davies et al
- Copyright date:
- 2009
- Notes:
- Copyright 2009 Davies et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
- Licence:
- CC Attribution (CC BY)
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