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Toward the discovery of vaccine adjuvants: coupling in silico screening and in vitro analysis of antagonist binding to human and mouse CCR4 receptors.

Abstract:

BACKGROUND: Adjuvants enhance or modify an immune response that is made to an antigen. An antagonist of the chemokine CCR4 receptor can display adjuvant-like properties by diminishing the ability of CD4+CD25+ regulatory T cells (Tregs) to down-regulate immune responses. METHODOLOGY: Here, we have used protein modelling to create a plausible chemokine receptor model with the aim of using virtual screening to identify potential small molecule chemokine antagonists. A combination of homology mod...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.pone.0008084

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Institution:
University of Oxford
Role:
Author
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Institution:
University of Oxford
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Role:
Author
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Funding agency for:
Beverley, P
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Funding agency for:
Flower, DR
Grant:
WT079287MA
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Funding agency for:
Flower, DR
Grant:
WT079287MA
Wellcome Trust More from this funder
Edward Jenner Institute for Vaccine Research More from this funder
Publisher:
Public Library of Science Publisher's website
Journal:
PloS One Journal website
Volume:
4
Issue:
11
Article number:
e8084
Publication date:
2009-01-01
DOI:
EISSN:
1932-6203
ISSN:
1932-6203
Source identifiers:
35017

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