Journal article icon

Journal article

Variant U1 snRNAs are implicated in human pluripotent stem cell maintenance and neuromuscular disease.

Abstract:

The U1 small nuclear (sn)RNA (U1) is a multifunctional ncRNA, known for its pivotal role in pre-mRNA splicing and regulation of RNA 3' end processing events. We recently demonstrated that a new class of human U1-like snRNAs, the variant (v)U1 snRNAs (vU1s), also participate in pre-mRNA processing events. In this study, we show that several human vU1 genes are specifically upregulated in stem cells and participate in the regulation of cell fate decisions. Significantly, ectopic expression of v...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

Actions


Access Document


Files:
Publisher copy:
10.1093/nar/gkw711

Authors


More by this author
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
More by this author
Department:
Oxford, MSD, Physiology Anatomy & Genetics
Role:
Author
More by this author
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
More by this author
Department:
Oxford, MSD, Physiology Anatomy & Genetics
Role:
Author
More by this author
Department:
Oxford, MSD, Physiology Anatomy & Genetics
Role:
Author
Expand authors...
More from this funder
Funding agency for:
Vazquez-Arango, Pilar
More from this funder
Funding agency for:
Vowles, Jane
More from this funder
Funding agency for:
Vowles, Jane
More from this funder
Funding agency for:
Vowles, Jane
More from this funder
Funding agency for:
Browne, Cathy
Expand funders...
Publisher:
Oxford University Press Publisher's website
Journal:
Nucleic acids research Journal website
Publication date:
2016-08-17
Acceptance date:
2016-08-04
DOI:
EISSN:
1362-4962
ISSN:
0305-1048
Pubs id:
pubs:640470
URN:
uri:e5b72760-084f-491b-9b99-4760ccb7ed7a
UUID:
uuid:e5b72760-084f-491b-9b99-4760ccb7ed7a
Local pid:
pubs:640470
Language:
English
Keywords:

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP