Effect of different 5-HT1A receptor antagonists in combination with paroxetine on expression of the immediate-early gene Arc in rat brain.

Journal article

Selective 5-HT(1A) receptor antagonists enhance the effect of selective serotonin reuptake inhibitors (SSRIs) on presynaptic 5-HT function, and have potential as antidepressant augmentation therapies. The present study tested the effect of different selective 5-HT(1A) receptor antagonists (WAY 100635, NAD-299, p-MPPI and LY 426965) in combination with a SSRI (paroxetine), on postsynaptic 5-HT function measured by increased expression of the immediate early gene, Arc. Paroxetine (5 mg/kg s.c.)...

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Authors: Tordera, R; Pei, Q; Newson, M; Gray, K; Sprakes, M

• Publication status: Published
• Journal: Neuropharmacology
• Volume: 44
• Issue: 7
• Pages: 893-902
• Publication date: 2003-06-01
• DOI: 10.1016/s0028-3908(03)00096-0
• EISSN: 1873-7064
• ISSN: 0028-3908
• Language: English
• Keywords: Receptors, Serotonin, 5-HT1; Receptors, Serotonin; Muscle Proteins; Aminopyridines; RNA, Messenger; Gene Expression; Apoptosis Regulatory Proteins; Pyridines; Male; Piperidines; Animals; Serotonin Antagonists; Serotonin Uptake Inhibitors; Rats; Piperazines; Benzopyrans; Paroxetine; Brain Chemistry; Rats, Sprague-Dawley