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Journal article

Changes in physiological, functional and structural markers of cystic fibrosis lung disease with treatment of a pulmonary exacerbation

Abstract:

Background: Clinical trials in cystic fibrosis (CF) have been hindered by the paucity of well characterised and clinically relevant outcome measures. Aim: To evaluate a range of conventional and novel biomarkers of CF lung disease in a multicentre setting as a contributing study in selecting outcome assays for a clinical trial of CFTR gene therapy. Methods: A multicentre observational study of adult and paediatric patients with CF (>10 years) treated for a physician-defined exacerbation of...

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Journal:
Thorax
Volume:
68
Issue:
6
Pages:
532-539
Publication date:
2013-06-05
DOI:
EISSN:
1468-3296
ISSN:
0040-6376
URN:
uuid:e59dab40-0388-4f09-9440-1c2241d1ce7d
Source identifiers:
403562
Local pid:
pubs:403562
Language:
English

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