Evidence of inbreeding depression on human height.

Journal article

Stature is a classical and highly heritable complex trait, with 80%-90% of variation explained by genetic factors. In recent years, genome-wide association studies (GWAS) have successfully identified many common additive variants influencing human height; however, little attention has been given to the potential role of recessive genetic effects. Here, we investigated genome-wide recessive effects by an analysis of inbreeding depression on adult height in over 35,000 people from 21 different ...

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Authors: McQuillan, R; Eklund, N; Pirastu, N; Kuningas, M; McEvoy, B

• Publication status: Published
• Journal: PLoS genetics
• Volume: 8
• Issue: 7
• Pages: e1002655
• Publication date: 2012-01-01
• DOI: 10.1371/journal.pgen.1002655
• EISSN: 1553-7404
• ISSN: 1553-7390
• Language: English
• Keywords: Adult; Family; Aged; Polymorphism, Single Nucleotide; Homozygote; Genome-Wide Association Study; Genetic Heterogeneity; Female; Male; Body Height; Humans; Quantitative Trait, Heritable; Databases, Genetic; Genes, Recessive; Middle Aged; Consanguinity; ROHgen Consortium