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Strong cation exchange (SCX) based analytical methods for the targeted analysis of protein post-translational modifications.

Abstract:

The multidimensional combination of strong cation exchange (SCX) chromatography and reversed phase chromatography has emerged as a powerful approach to separate peptides originating from complex samples such as digested cellular lysates or tissues before analysis by mass spectrometry, enabling the identification of over 10,000s of peptides and thousands of proteins in a single sample. Although, such multidimensional chromatography approaches are powerful, the in-depth analysis of protein post...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Physical and Theoretical Chem
Role:
Author
Journal:
Current opinion in biotechnology
Volume:
22
Issue:
1
Pages:
9-16
Publication date:
2011-02-05
DOI:
EISSN:
1879-0429
ISSN:
0958-1669
URN:
uuid:e57ecca2-4b22-4b95-afba-a15e0adee2e4
Source identifiers:
384573
Local pid:
pubs:384573

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