The deubiquitinating enzyme USP1 regulates the Fanconi anemia pathway.

Journal article

Protein ubiquitination and deubiquitination are dynamic processes implicated in the regulation of numerous cellular pathways. Monoubiquitination of the Fanconi anemia (FA) protein FANCD2 appears to be critical in the repair of DNA damage because many of the proteins that are mutated in FA are required for FANCD2 ubiquitination. By screening a gene family RNAi library, we identify the deubiquitinating enzyme USP1 as a novel component of the Fanconi anemia pathway. Inhibition of USP1 leads to h...

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Authors: Nijman, S; Huang, T; Dirac, A; Brummelkamp, T; Kerkhoven, R

• Journal: Molecular cell
• Volume: 17
• Issue: 3
• Pages: 331-339
• Publication date: 2005-02-01
• DOI: 10.1016/j.molcel.2005.01.008
• EISSN: 1097-4164
• ISSN: 1097-2765
• Language: English
• Keywords: Chromosome Aberrations; Mutation; Fanconi Anemia Complementation Group D2 Protein; Endopeptidases; Ubiquitin; Proteasome Endopeptidase Complex; Cell Cycle; Humans; Cell Line; Mice; RNA, Small Interfering; Gene Library; Mitomycin; Base Sequence; Nuclear Proteins; Animals; DNA Repair; Chromatin; RNA Interference; Fanconi Anemia