- Abstract:
-
Global gene expression profiling of highly purified 5q-deleted CD34+CD38(-)Thy1+ cells in 5q- myelodysplastic syndromes (MDSs) supported that they might originate from and outcompete normal CD34+CD38(-)Thy1+ hematopoietic stem cells. Few but distinct differences in gene expression distinguished MDS and normal stem cells. Expression of BMI1, encoding a critical regulator of self-renewal, was up-regulated in 5q- stem cells. Whereas multiple previous MDS genetic screens failed to identify altere...
Expand abstract - Publisher copy:
- 10.1182/blood-2007-03-079368
-
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- Journal:
- Blood
- Volume:
- 110
- Issue:
- 8
- Pages:
- 3005-3014
- Publication date:
- 2007-10-05
- DOI:
- EISSN:
-
1528-0020
- ISSN:
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0006-4971
- URN:
-
uuid:e578994d-ed47-4468-93e4-3d5b972dbc92
- Source identifiers:
-
324060
- Local pid:
- pubs:324060
- Language:
- English
- Keywords:
- Copyright date:
- 2007
Journal article
The molecular signature of MDS stem cells supports a stem-cell origin of 5q myelodysplastic syndromes.
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