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The molecular signature of MDS stem cells supports a stem-cell origin of 5q myelodysplastic syndromes.

Abstract:

Global gene expression profiling of highly purified 5q-deleted CD34+CD38(-)Thy1+ cells in 5q- myelodysplastic syndromes (MDSs) supported that they might originate from and outcompete normal CD34+CD38(-)Thy1+ hematopoietic stem cells. Few but distinct differences in gene expression distinguished MDS and normal stem cells. Expression of BMI1, encoding a critical regulator of self-renewal, was up-regulated in 5q- stem cells. Whereas multiple previous MDS genetic screens failed to identify altere...

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Journal:
Blood
Volume:
110
Issue:
8
Pages:
3005-3014
Publication date:
2007-10-05
DOI:
EISSN:
1528-0020
ISSN:
0006-4971
URN:
uuid:e578994d-ed47-4468-93e4-3d5b972dbc92
Source identifiers:
324060
Local pid:
pubs:324060

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