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Increased 5-HT(2A) receptor binding in euthymic, medication-free patients recovered from depression: a positron emission study with [(11)C]MDL 100,907.

Abstract:

OBJECTIVE: A previous positron emission tomography (PET) study reported increased serotonin 5-HT(2A) receptor binding in unmedicated depressed patients with high scores on the Dysfunctional Attitudes Scale. The purpose of the present study was to use the highly selective 5-HT(2A) receptor ligand [(11)C]MDL 100,907 in a PET imaging paradigm to assess 1) 5-HT(2A) receptor binding potential in euthymic subjects with a history of recurrent depression and 2) the relationship between receptor bindi...

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Publication status:
Published

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Publisher copy:
10.1176/appi.ajp.163.9.1580

Authors


Bhagwagar, Z More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Psychiatry
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Journal:
The American journal of psychiatry
Volume:
163
Issue:
9
Pages:
1580-1587
Publication date:
2006-09-05
DOI:
EISSN:
1535-7228
ISSN:
0002-953X
URN:
uuid:e576ca8f-54f0-46f7-907e-f0b7dd761d4f
Source identifiers:
139778
Local pid:
pubs:139778

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