Cell differentiation versus cell death: extracellular glucose is a key determinant of cell fate following oxidative stress exposure

Journal article

Cells, particularly mechano-sensitive musculoskeletal cells such as tenocytes, routinely encounter oxidative stress. Oxidative stress can not only stimulate tissue repair, but also cause damage leading to tissue degeneration. As diabetes is associated with increased oxidative damage as well as increased risk of tendon degeneration, the aim of this study was to determine if extracellular glucose levels alter the response of tendon cells to oxidative stress. Primary human tenocytes were culture...

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Authors: Poulsen, R; Knowles, H; Carr, A; Hulley, P

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: Nature Publishing Group
• Journal: Cell death and disease
• Volume: 5
• Issue: 2
• Pages: e1074
• Publication date: 2014-02-20
• Acceptance date: 2013-12-02
• DOI: 10.1038/cddis.2014.52
• EISSN: 2041-4889
• ISSN: 2041-4889
• Language: English
• Keywords: glucose; transcription, genetic; cell differentiation; basic helix-loop-helix transcription factors; forkhead transcription factors; apoptosis regulatory proteins; apoptosis; microRNAs; sirtuin 3; SBTMR; tumor suppressor protein p53; transfection; enzyme activation; collagen; gene expression regulation; hypoxia-inducible factor 1, alpha subunit; cells, cultured; proto-oncogene proteins; membrane proteins; RNA interference; SOX9 transcription factor; humans; mitogen-activated protein kinase 14; oxidants; oxidative stress; tendons