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The critical role of agrin in the hematopoietic stem cell niche.

Abstract:

Hematopoiesis is the process leading to the sustained production of blood cells by hematopoietic stem cells (HSCs). Growth, survival, and differentiation of HSCs occur in specialized microenvironments called "hematopoietic niches," through molecular cues that are only partially understood. Here we show that agrin, a proteoglycan involved in the neuromuscular junction, is a critical niche-derived signal that controls survival and proliferation of HSCs. Agrin is expressed by multipotent nonhema...

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Authors


Anselmo, A More by this author
Cibella, J More by this author
Soldani, C More by this author
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Journal:
Blood
Volume:
118
Issue:
10
Pages:
2733-2742
Publication date:
2011-09-05
DOI:
EISSN:
1528-0020
ISSN:
0006-4971
URN:
uuid:e55653dd-88e4-4f77-8e55-0ecc8eab01fd
Source identifiers:
426265
Local pid:
pubs:426265

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