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Negative autoregulation of BMP dependent transcription by SIN3B splicing reveals a role for RBM39.

Abstract:

BMP signalling is negatively autoregulated by several genes including SMAD6, Noggin and Gremlin, and autoregulators are possible targets for enhancing BMP signalling in disorders such as fibrosis and pulmonary hypertension. To identify novel negative regulators of BMP signalling, we used siRNA screening in mouse C2C12 cells with a BMP-responsive luciferase reporter. Knockdown of several splicing factors increased BMP4-dependent transcription and target gene expression. Knockdown of RBM39 prod...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1038/srep28210

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Institution:
University of Oxford
Department:
Oxford, MSD, NDM, Human Genetics Wt Centre
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDM, Human Genetics Wt Centre
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDM, Human Genetics Wt Centre
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDM, Human Genetics Wt Centre
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDM, Human Genetics Wt Centre
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Grant:
RG/10/17/28553, RG/11/1/28684, RE/13/1/30181, CH/09/003/26631, RM/13/3/30159
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Grant:
083228, 090532/Z/09/Z
Publisher:
Nature Publishing Group Publisher's website
Journal:
Scientific Reports Journal website
Volume:
6
Pages:
28210
Publication date:
2016-06-21
DOI:
EISSN:
2045-2322
ISSN:
2045-2322
URN:
uuid:e5527378-cc9d-48a8-875c-06ed606e3d25
Source identifiers:
630054
Local pid:
pubs:630054
Language:
English

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