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Journal article

Molecular insights into Down syndrome-associated leukemia.

Abstract:

PURPOSE OF REVIEW: Four years ago it was discovered that nearly all cases of transient myeloproliferative disorder and acute megakaryocytic leukemia in children with Down syndrome acquire mutations in the hematopoietic transcription factor gene GATA1. Studies within the past year, described within this review, have provided tremendous insights into the role of GATA1 mutations in these malignancies. RECENT FINDINGS: In the past year, our understanding of the molecular and cellular consequences...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Molecular Medicine, Biomedical Research
Role:
Author
Journal:
Current opinion in pediatrics
Volume:
19
Issue:
1
Pages:
9-14
Publication date:
2007-02-05
DOI:
EISSN:
1531-698X
ISSN:
1040-8703
URN:
uuid:e544e0a5-1a92-4486-a76e-bd9001f957e6
Source identifiers:
33726
Local pid:
pubs:33726

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