The novel centrosomal associated protein CEP55 is present in the spindle midzone and the midbody.

Journal article

Centrosomes are the major microtubule nucleating center in the cell; they also contribute to spindle pole organization and play a role in cell cycle progression as well as completing cytokinesis. Here we describe the molecular characterization of a novel human gene, CEP55, located in 10q23.33 that is expressed in multiple tissues and various cancer cell lines. Sequence analysis of the cDNA predicted a protein of 464 amino acids with several putative coiled-coil domains that are responsible fo...

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Authors: Martinez-Garay, I; Rustom, A; Gerdes, H; Kutsche, K

• Journal: Genomics
• Volume: 87
• Issue: 2
• Pages: 243-253
• Publication date: 2006-02-01
• DOI: 10.1016/j.ygeno.2005.11.006
• EISSN: 1089-8646
• ISSN: 0888-7543
• Language: English
• Keywords: DNA Primers; Chromosomes, Human, Pair 10; Humans; Immunoprecipitation; Molecular Sequence Data; Mitotic Spindle Apparatus; Reverse Transcriptase Polymerase Chain Reaction; Translocation, Genetic; Green Fluorescent Proteins; Base Sequence; Cell Cycle Proteins; Nuclear Proteins; Blotting, Northern; DNA, Complementary; Chromosomes, Human, X