- Abstract:
-
In pancreatic acinar cells, low, threshold concentrations of acetylcholine (ACh) or cholecystokinin (CCK) induce repetitive local cytosolic Ca2+ spikes in the apical pole, while higher concentrations elicit global signals. We have investigated the process that transforms local Ca2+ spikes to global Ca2+ transients, focusing on the interactions of multiple intracellular messengers. ACh-elicited local Ca2+ spikes were transformed into a global sustained Ca2+ response by cyclic ADP-ribose (cADPR...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1093/emboj/21.5.909
-
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- Journal:
- The EMBO journal
- Volume:
- 21
- Issue:
- 5
- Pages:
- 909-919
- Publication date:
- 2002-03-05
- DOI:
- EISSN:
-
1460-2075
- ISSN:
-
0261-4189
- URN:
-
uuid:e52da610-b6ba-4923-bcda-5b33ea2a327e
- Source identifiers:
-
106304
- Local pid:
- pubs:106304
- Language:
- English
- Keywords:
- Copyright date:
- 2002
Journal article
Transformation of local Ca2+ spikes to global Ca2+ transients: the combinatorial roles of multiple Ca2+ releasing messengers.
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