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Induced pluripotent stem cells: challenges and opportunities for cancer immunotherapy.

Abstract:

Despite recent advances in cancer treatment over the past 30 years, therapeutic options remain limited and do not always offer a cure for malignancy. Given that tumor-associated antigens (TAA) are, by definition, self-proteins, the need to productively engage autoreactive T cells remains at the heart of strategies for cancer immunotherapy. These have traditionally focused on the administration of autologous monocyte-derived dendritic cells (moDC) pulsed with TAA, or the ex vivo expansion and ...

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Publisher copy:
10.3389/fimmu.2014.00176

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
Journal:
Frontiers in immunology
Volume:
5
Pages:
176
Publication date:
2014-01-01
DOI:
EISSN:
1664-3224
URN:
uuid:e52c3963-a0d5-41ac-841e-bb87cb7e3cd2
Source identifiers:
465880
Local pid:
pubs:465880

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