Journal article
Mutant muscle LIM protein C58G causes cardiomyopathy through protein depletion
- Abstract:
-
Cysteine and glycine rich protein 3 (CSRP3) encodes Muscle LIM Protein (MLP), a well-established disease gene for Hypertrophic Cardiomyopathy (HCM). MLP, in contrast to the proteins encoded by the other recognised HCM disease genes, is non-sarcomeric, and has important signalling functions in cardiomyocytes. To gain insight into the disease mechanisms involved, we generated a knock-in mouse (KI) model, carrying the well documented HCM-causing CSRP3 mutation C58G. In vivo phenotyping of homoz...
Expand abstract
- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Access Document
- Files:
-
-
(Preview, pdf, 2.8MB, Terms of use)
-
- Publisher copy:
- 10.1016/j.yjmcc.2018.07.248
Authors
Funding
+ Wellcome Trust
More from this funder
Funding agency for:
Goel, A
Watkins, H
Grant:
NNF15CC0018486
NNF15CC0018486
+ TriPartite Immunometabolism Consortium [TrIC]- Novo
Nordisk Foundation
More from this funder
Funding agency for:
Goel, A
Watkins, H
Grant:
NNF15CC0018486
NNF15CC0018486
+ British Heart Foundation
More from this funder
Funding agency for:
Goel, A
Kyriakou, T
Watkins, H
Grant:
NNF15CC0018486
HEALTH-F2-2013-601456
NNF15CC0018486
+ BHF Centre of Research Excellence
More from this funder
Funding agency for:
Goel, A
Grant:
NNF15CC0018486
+ European Commission
More from this funder
Funding agency for:
Ehsan, M
Goel, A
Kyriakou, T
Watkins, H
Grant:
751739
NNF15CC0018486
HEALTH-F2-2013-601456
NNF15CC0018486
Bibliographic Details
- Publisher:
- Elsevier
- Journal:
- Journal of Molecular and Cellular Cardiology More from this journal
- Volume:
- 121
- Issue:
- 1
- Pages:
- 287-296
- Publication date:
- 2018-07-23
- Acceptance date:
- 2018-07-21
- DOI:
- EISSN:
-
1095-8584
- ISSN:
-
0022-2828
Item Description
- Keywords:
- Pubs id:
-
pubs:890974
- UUID:
-
uuid:e5280b23-df9c-48b2-a5e6-edb0aab4fc00
- Local pid:
-
pubs:890974
- Deposit date:
-
2018-07-24
Terms of use
- Copyright holder:
- Ehsan et al
- Copyright date:
- 2018
- Notes:
- © 2018 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license.
- Licence:
- CC Attribution (CC BY)
Metrics
If you are the owner of this record, you can report an update to it here: Report update to this record