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Early antiretroviral therapy reduces hiv dna following perinatal HIV infection

Abstract:

: The impact of antiretroviral therapy (ART) on the size of the HIV reservoir has implications for virological remission in adults, but is not well characterised in perinatally acquired infection (PaHIV). In a prospective observational study of 20 children with PaHIV and sustained viral suppression on ART for >5 years, proviral DNA was significantly higher in deferred (>4 years) versus early (first year of life) ART recipients (p = 0.0062), and correlated with age of initiation (p = 0.1...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1097/QAD.0000000000001565

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Department:
Oxford, MSD, NDM, NDM Experimental Medicine
Hopkins, E More by this author
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Department:
Oxford, MSD, NDM, NDM Experimental Medicine
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Publisher:
Lippincott, Williams & Wilkins Publisher's website
Journal:
AIDS Journal website
Volume:
31
Issue:
13
Pages:
1847–1851
Publication date:
2017-06-12
DOI:
EISSN:
1473-5571
ISSN:
0269-9370
Pubs id:
pubs:523487
URN:
uri:e527c3d6-a4d8-455f-af43-f52b089f3d86
UUID:
uuid:e527c3d6-a4d8-455f-af43-f52b089f3d86
Local pid:
pubs:523487

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