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Journal article

Treg cell function in rheumatoid arthritis is compromised by ctla-4 promoter methylation resulting in a failure to activate the indoleamine 2,3-dioxygenase pathway.

Abstract:

OBJECTIVE: Functionally impaired Treg cells expressing abnormally low levels of CTLA-4 have been well documented in rheumatoid arthritis (RA). However, the molecular defect underlying this reduced expression is unknown. The aims of this study were to assess the role of DNA methylation in regulating CTLA-4 expression in Treg cells isolated from RA patients and to elucidate the mechanism of their reduced suppressor function. METHODS: CTLA-4 expression in Treg cells from RA patients and healthy ...

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Publication status:
Published

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Publisher copy:
10.1002/art.38715

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Publisher:
John Wiley and Sons Inc.
Journal:
Arthritis and rheumatology (Hoboken, N.J.)
Volume:
66
Issue:
9
Pages:
2344-2354
Publication date:
2014-09-05
DOI:
EISSN:
2326-5205
ISSN:
2326-5191
URN:
uuid:e525afef-4306-44d0-817f-ca8f87756857
Source identifiers:
445348
Local pid:
pubs:445348

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