Intratumoral lymphangiogenesis and lymph node metastasis in head and neck cancer.

Journal article

How tumors access and spread via the lymphatics is not understood. Although it is clear that dissemination via the blood system involves hemangiogenesis, it is uncertain whether tumors also induce lymphangiogenesis or simply invade existing peritumoral vessels. To address the issue we quantitated tumor lymph vessels in archival specimens of head and neck cancer by immunostaining for the recently described lymphatic endothelial marker LYVE-1, the vascular endothelial marker CD34, and the pKi67...

Expand abstract

Authors: Beasley, N; Prevo, R; Banerji, S; Leek, R; Moore, J

• Publication status: Published
• Journal: Cancer research
• Volume: 62
• Issue: 5
• Pages: 1315-1320
• Publication date: 2002-03-01
• EISSN: 1538-7445
• ISSN: 0008-5472
• Language: English
• Keywords: Adolescent; Endothelial Growth Factors; Head and Neck Neoplasms; Vascular Endothelial Growth Factor C; Carcinoma, Squamous Cell; Adult; Middle Aged; Aged; Lymphatic Metastasis; Female; Male; Cell Division; Aged, 80 and over; Neovascularization, Pathologic; Humans; Lymphatic System; Neoplasm Invasiveness