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Review article: the therapeutic potential of 5-HT3 receptor antagonists in the treatment of irritable bowel syndrome.

Abstract:

There is evidence from studies, in both animals and humans, that 5-HT3 receptor blockade has potential value in the treatment of irritable bowel syndrome, particularly in those patients with diarrhoea-predominant bowel habits. New findings suggest that 5-HT3 receptors exist on gut afferent neurones and that their activation by locally released 5-HT leads to visceral nociceptive stimulation, in addition to increased neuronally-mediated motor and secretory activity. If this concept is validated...

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Publication status:
Published

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Authors


Humphrey, PP More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Structural Genomics Consortium
Clayton, N More by this author
Kozlowski, K More by this author
Publisher:
Blackwell Publishing Ltd.
Journal:
Alimentary pharmacology and therapeutics
Volume:
13 Suppl 2
Issue:
2
Pages:
31-38
Publication date:
1999-05-05
DOI:
EISSN:
1365-2036
ISSN:
0269-2813
URN:
uuid:e50fb3b0-8a11-496e-b7b5-28f12c64295d
Source identifiers:
31532
Local pid:
pubs:31532

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