Cholesterol and the risk of renal dysfunction in apparently healthy men.

Journal article

Despite extensive knowledge about abnormal lipid patterns in patients with end-stage renal disease, the association between cholesterol and the development of renal dysfunction is unclear. We evaluated this association in a prospective cohort study among 4,483 initially healthy men participating in the Physicians' Health Study who provided blood samples in 1982 and 1996. Main outcome measures were elevated creatinine, defined as >/= 1.5 mg/dl (133 micromol/L), and reduced estimated creatin...

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Authors: Schaeffner, E; Kurth, T; Curhan, G; Glynn, R; Rexrode, K

• Publication status: Published
• Journal: Journal of the American Society of Nephrology : JASN
• Volume: 14
• Issue: 8
• Pages: 2084-2091
• Publication date: 2003-08-01
• EISSN: 1533-3450
• ISSN: 1046-6673
• Language: English
• Keywords: Odds Ratio; Treatment Outcome; Cholesterol; Cohort Studies; Risk; Glomerular Filtration Rate; Time Factors; Edetic Acid; Cholesterol, HDL; Humans; Creatinine; Prospective Studies; Male; Kidney Failure, Chronic; Multivariate Analysis; Kidney Diseases; Lipid Metabolism; Logistic Models