- Abstract:
-
CA9 is a membrane-tethered, carbonic anhydrase (CA) enzyme, expressed mainly at the external surface of cells, that catalyzes reversible CO(2) hydration. Expression is greatly enhanced in many tumors, particularly in aggressive carcinomas. The functional role of CA9 in tumors is not well established. Here we show that CA9, when expressed heterologously in cultured spheroids (0.5-mm diameter, ~25,000 cells) of RT112 cells (derived from bladder carcinoma), induces a near-uniform intracellular p...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1074/jbc.m801330200
-
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- Journal:
- The Journal of biological chemistry
- Volume:
- 283
- Issue:
- 29
- Pages:
- 20473-20483
- Publication date:
- 2008-07-05
- DOI:
- EISSN:
-
1083-351X
- ISSN:
-
0021-9258
- URN:
-
uuid:e50c333b-007c-486d-be3c-89b3a08c5bde
- Source identifiers:
-
106435
- Local pid:
- pubs:106435
- Copyright date:
- 2008
Journal article
Tumor-associated carbonic anhydrase 9 spatially coordinates intracellular pH in three-dimensional multicellular growths.
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