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Journal article

Tumor-associated carbonic anhydrase 9 spatially coordinates intracellular pH in three-dimensional multicellular growths.

Abstract:

CA9 is a membrane-tethered, carbonic anhydrase (CA) enzyme, expressed mainly at the external surface of cells, that catalyzes reversible CO(2) hydration. Expression is greatly enhanced in many tumors, particularly in aggressive carcinomas. The functional role of CA9 in tumors is not well established. Here we show that CA9, when expressed heterologously in cultured spheroids (0.5-mm diameter, ~25,000 cells) of RT112 cells (derived from bladder carcinoma), induces a near-uniform intracellular p...

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Publication status:
Published

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Publisher copy:
10.1074/jbc.m801330200

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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
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Journal:
Journal of biological chemistry
Volume:
283
Issue:
29
Pages:
20473-20483
Publication date:
2008-07-01
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
Source identifiers:
106435
Language:
English
Keywords:
Pubs id:
pubs:106435
UUID:
uuid:e50c333b-007c-486d-be3c-89b3a08c5bde
Local pid:
pubs:106435
Deposit date:
2012-12-19

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