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Journal article

Tumor-associated carbonic anhydrase 9 spatially coordinates intracellular pH in three-dimensional multicellular growths.

Abstract:

CA9 is a membrane-tethered, carbonic anhydrase (CA) enzyme, expressed mainly at the external surface of cells, that catalyzes reversible CO(2) hydration. Expression is greatly enhanced in many tumors, particularly in aggressive carcinomas. The functional role of CA9 in tumors is not well established. Here we show that CA9, when expressed heterologously in cultured spheroids (0.5-mm diameter, ~25,000 cells) of RT112 cells (derived from bladder carcinoma), induces a near-uniform intracellular p...

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Publication status:
Published

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Publisher copy:
10.1074/jbc.m801330200

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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics, BHF Centre of Research Excellence
Role:
Author
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Journal:
The Journal of biological chemistry
Volume:
283
Issue:
29
Pages:
20473-20483
Publication date:
2008-07-05
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
URN:
uuid:e50c333b-007c-486d-be3c-89b3a08c5bde
Source identifiers:
106435
Local pid:
pubs:106435

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