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Journal article

Multipoint linkage-disequilibrium mapping narrows location interval and identifies mutation heterogeneity.

Abstract:

Single-nucleotide polymorphism (SNP) genotypes were recently examined in an 890-kb region flanking the human gene CYP2D6. Single-marker and haplotype-based analyses identified, with genomewide significance (P < 10-7), a 403-kb interval displaying strong linkage disequilibrium (LD) with predicted poor-metabolizer phenotype. However, the width of this interval makes the location of causal variants difficult: for example, the interval contains seven known or predicted genes in addition to CYP...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.2235031100

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, WTC Human Genetics
Whittaker, JC More by this author
Hosking, LK More by this author
Balding, DJ More by this author
Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
100
Issue:
23
Pages:
13442-13446
Publication date:
2003-11-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:e50b9db0-f699-4cbe-ab1d-515b2a080571
Source identifiers:
32533
Local pid:
pubs:32533

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