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Journal article

Loss of endogenous bone morphogenetic protein-6 aggravates renal fibrosis.

Abstract:

Bone morphogenetic protein-6 (BMP-6) suppresses inflammatory genes in renal proximal tubular cells and regulates iron metabolism by inducing hepcidin. In diabetic patients, an increase of myofibroblast progenitor cells (MFPCs), also known as fibrocytes, was found to be associated with decreased BMP-6 expression. We hypothesized that loss of endogenous BMP-6 would aggravate renal injury and fibrosis. Wild type (WT) and BMP-6 null mice underwent unilateral ureteral obstruction. In WT mice, uret...

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Journal:
The American journal of pathology
Volume:
178
Issue:
3
Pages:
1069-1079
Publication date:
2011-03-05
DOI:
EISSN:
1525-2191
ISSN:
0002-9440
URN:
uuid:e5043685-c63f-4ce8-9b53-f455f04a241a
Source identifiers:
245635
Local pid:
pubs:245635

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