Loss of endogenous bone morphogenetic protein-6 aggravates renal fibrosis.

Journal article

Bone morphogenetic protein-6 (BMP-6) suppresses inflammatory genes in renal proximal tubular cells and regulates iron metabolism by inducing hepcidin. In diabetic patients, an increase of myofibroblast progenitor cells (MFPCs), also known as fibrocytes, was found to be associated with decreased BMP-6 expression. We hypothesized that loss of endogenous BMP-6 would aggravate renal injury and fibrosis. Wild type (WT) and BMP-6 null mice underwent unilateral ureteral obstruction. In WT mice, uret...

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Authors: Dendooven, A; van Oostrom, O; van der Giezen, D; Leeuwis, J; Snijckers, C

• Journal: American journal of pathology
• Volume: 178
• Issue: 3
• Pages: 1069-1079
• Publication date: 2011-03-01
• DOI: 10.1016/j.ajpath.2010.12.005
• EISSN: 1525-2191
• ISSN: 0002-9440
• Language: English
• Keywords: Animals; Gene Expression Regulation; Kidney Tubules; Signal Transduction; Plasminogen Activator Inhibitor 1; Connective Tissue Growth Factor; Bone Morphogenetic Protein 6; Mice; Fibroblasts; Cadherins; Heme Oxygenase-1; Actins; Stem Cells; Kidney; Transforming Growth Factor beta; Fibrosis; Inflammation; Body Weight; Iron; Extracellular Matrix