- Abstract:
-
OBJECTIVES: The HIV-1 Nef protein selectively downregulates human leukocyte antigen (HLA)-A and HLA-B but not HLA-C molecules on the surface of infected cells. This allows HIV-infected cells to evade recognition by most cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells. We investigated the recognition of an HLA-Cw4-restricted HIV-1 gp120 epitope SFNCGGEFF (SF9) and its variant SFNCGGEFL (SL9) by T cells and NK receptors. DESIGN AND METHOD: Recognition of HIV-1 gp120 peptides (SF9 a...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1097/qad.0b013e32831fb55a
-
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- Journal:
- AIDS (London, England)
- Volume:
- 23
- Issue:
- 2
- Pages:
- 189-193
- Publication date:
- 2009-01-05
- DOI:
- EISSN:
-
1473-5571
- ISSN:
-
0269-9370
- URN:
-
uuid:e4feab80-7245-4c93-9bf6-199c4fe02b79
- Source identifiers:
-
95289
- Local pid:
- pubs:95289
- Copyright date:
- 2009
Journal article
Reciprocal recognition of an HLA-Cw4-restricted HIV-1 gp120 epitope by CD8+ T cells and NK cells.
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