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Reciprocal recognition of an HLA-Cw4-restricted HIV-1 gp120 epitope by CD8+ T cells and NK cells.

Abstract:

OBJECTIVES: The HIV-1 Nef protein selectively downregulates human leukocyte antigen (HLA)-A and HLA-B but not HLA-C molecules on the surface of infected cells. This allows HIV-infected cells to evade recognition by most cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells. We investigated the recognition of an HLA-Cw4-restricted HIV-1 gp120 epitope SFNCGGEFF (SF9) and its variant SFNCGGEFL (SL9) by T cells and NK receptors. DESIGN AND METHOD: Recognition of HIV-1 gp120 peptides (SF9 a...

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Publication status:
Published

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Journal:
AIDS (London, England)
Volume:
23
Issue:
2
Pages:
189-193
Publication date:
2009-01-05
DOI:
EISSN:
1473-5571
ISSN:
0269-9370
URN:
uuid:e4feab80-7245-4c93-9bf6-199c4fe02b79
Source identifiers:
95289
Local pid:
pubs:95289

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