Journal article

New Pyrimidinone Bearing Aminomethylenes and Schiff Bases as Potent Antioxidant, Antibacterial, SARS-CoV-2, and COVID-19 Main Protease M Pro Inhibitors: Design, Synthesis, Bioactivities, and Computational Studies

Abstract:: New 2-thioxopyrimidinone derivatives (A1–A10) were synthesized in 87–96% yields via a simple three-component condensation reaction. These compounds were screened extensively through in vitro assays for antioxidant and antibacterial investigations. The DPPH assays resulted in the excellent potency of A6–A10 as antioxidants with IC50 values of 0.83 ± 0.125, 0.90 ± 0.77, 0.36 ± 0.063, 1.4 ± 0.07, and 1.18 ± 0.06 mg/mL, which were much better than 1.79 ± 0.045 mg/mL for the reference ascorbic aci...
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Publication status:: Published

Peer review status:: Peer reviewed

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APA Style

Sarfraz, M., Ayyaz, M., Rauf, A., Yaqoob, A., Tooba, Arif Ali, M., Siddique, S. A., Qureshi, A. M., Sarfraz, M. H., Aljowaie, R. M., Almutairi, S. M., & Arshad, M. (2024). New Pyrimidinone Bearing Aminomethylenes and Schiff Bases as Potent Antioxidant, Antibacterial, SARS-CoV-2, and COVID-19 Main Protease M Pro Inhibitors: Design, Synthesis, Bioactivities, and Computational Studies. ACS Omega, 9(24), 25730–25747.

MLA Style

Sarfraz, M., et al. “New Pyrimidinone Bearing Aminomethylenes and Schiff Bases as Potent Antioxidant, Antibacterial, SARS-CoV-2, and COVID-19 Main Protease M Pro Inhibitors: Design, Synthesis, Bioactivities, and Computational Studies.” ACS Omega, vol. 9, no. 24, American Chemical Society, 2024, pp. 25730–47.

Chicago Style

Sarfraz, M, M Ayyaz, A Rauf, A Yaqoob, Tooba, M Arif Ali, SA Siddique, et al. 2024. “New Pyrimidinone Bearing Aminomethylenes and Schiff Bases as Potent Antioxidant, Antibacterial, SARS-CoV-2, and COVID-19 Main Protease M Pro Inhibitors: Design, Synthesis, Bioactivities, and Computational Studies.” ACS Omega 9 (24): 25730–47.
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Files:: Sarfraz_et_al_2024_New_Pyrimidinone_Bearing.pdf

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Publisher copy:: 10.1021/acsomega.3c09393

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+ Sarfraz, M More by this author

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+ Ayyaz, M More by this author

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+ Rauf, A More by this author

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+ Yaqoob, A More by this author

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Bibliographic Details

Publisher:: American Chemical Society
Journal:: ACS Omega More from this journal
Volume:: 9
Issue:: 24
Pages:: 25730-25747
Publication date:: 2024-06-04
Acceptance date:: 2024-05-23
DOI:: 10.1021/acsomega.3c09393
EISSN:: 2470-1343
ISSN:: 2470-1343

Item Description

Language:: English
Source identifiers:: 2052725
Deposit date:: 2024-06-19

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Copyright date:: 2024

Licence:: CC Attribution (CC BY)

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