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A review on metaanalysis of biomarkers: promises and pitfalls.

Abstract:

BACKGROUND: The last 30 years have seen an exponential increase in metaanalyses. By combining multiple studies, metaanalysis can provide an overview of the totality of evidence on a particular question and the statistical power needed to reduce random error and produce precise estimates of even modest effect sizes. This capability is of particular value when many small studies address similar questions [such as in the investigation of novel cardiovascular disease (CVD) biomarkers]. To provide...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Trial Service Unit
Journal:
Clinical chemistry
Volume:
58
Issue:
8
Pages:
1192-1204
Publication date:
2012-08-05
DOI:
EISSN:
1530-8561
ISSN:
0009-9147
URN:
uuid:e4f75396-f8c4-4cde-b75c-61cd53f7465b
Source identifiers:
339732
Local pid:
pubs:339732

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