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Diphosphonates and polyphosphates in medicine

Abstract:

Compounds containing phosphorus with P O P bonds (for example PPi) or P C P bonds (diphosphonates) bind strongly to crystals of hydroxyapatite and inhibit their growth and aggregation as well as their rates of dissolution. Both groups of compounds inhibit experimentally induced ectopic calcification in animals. The diphosphonates, which are more stable than PPi, also inhibit bone resorption and bone turnover in various experimental systems; PPi occurs naturally in body fluids and mineralized ...

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Authors


Russell, RGG More by this author
Journal:
British Journal of Hospital Medicine
Volume:
14
Issue:
3
Pages:
297-314
Publication date:
1975
ISSN:
0007-1064
URN:
uuid:e4ecc5fa-03d6-41dd-b979-c100bc9b3ece
Source identifiers:
109519
Local pid:
pubs:109519
Language:
English

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