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A secreted fluorescent reporter targeted to pituitary growth hormone cells in transgenic mice.

Abstract:

In stable transfection experiments in the GH-producing GC cell line, a construct containing the entire signal peptide and the first 22 residues of human GH linked in frame with enhanced green fluorescent protein (eGFP), produced brightly fluorescent cells with a granular distribution of eGFP. This eGFP reporter was then inserted into a 40-kb cosmid transgene containing the locus control region for the hGH gene and used to generate transgenic mice. Anterior pituitaries from these GH-eGFP trans...

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Publication status:
Published

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Publisher copy:
10.1210/en.141.12.4681

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Journal:
Endocrinology
Volume:
141
Issue:
12
Pages:
4681-4689
Publication date:
2000-12-05
DOI:
EISSN:
1945-7170
ISSN:
0013-7227
URN:
uuid:e4ec447b-25aa-4227-93e0-83fea7415414
Source identifiers:
280828
Local pid:
pubs:280828

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