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Detection of HIV type 1 gag-specific CD4(+) T cell responses in acutely infected infants.

Abstract:

Multiple HIV-1-specific cytokine and proliferative responses by CD4(+) T cells have not been studied in acutely infected infants. Using an intracellular cytokine staining assay, 34 untreated clade C HIV-1-infected infants (2-102 days old) were assessed for IFN-gamma, 28/34 for IL-2, and 26/34 for TNF-alpha responses to all HIV-1 proteins. Responses were detected in 29%, 36%, and 15% of infants, respectively. Twelve of the original 34 infants were then studied longitudinally for 14 months to d...

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Publisher copy:
10.1089/aid.2007.0096

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Journal:
AIDS research and human retroviruses
Volume:
24
Issue:
2
Pages:
265-270
Publication date:
2008-02-05
DOI:
EISSN:
1931-8405
ISSN:
0889-2229
URN:
uuid:e4e8d883-e512-4d5d-901c-c6ea4a28574f
Source identifiers:
191159
Local pid:
pubs:191159

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