- Abstract:
-
BACKGROUND and AIMS: It is a challenge to determine the dynamics of stem cells within human epithelial tissues such as colonic crypts. By tracking methylation patterns of nonexpressed genes, we have been able to determine how rapidly individual stem cells became dominant within a human colonic crypt. We also analyzed methylation patterns to study clonal expansion of entire crypts via crypt fission. METHODS: Colonic mucosa was obtained from 9 patients who received surgery for colorectal cancer...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1053/j.gastro.2010.12.036
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- Journal:
- Gastroenterology
- Volume:
- 140
- Issue:
- 4
- Pages:
- 1241-1250.e1-9
- Publication date:
- 2011-04-05
- DOI:
- EISSN:
-
1528-0012
- ISSN:
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0016-5085
- URN:
-
uuid:e4db6283-8d84-4fcc-9c3b-dde833e8d8f3
- Source identifiers:
-
135208
- Local pid:
- pubs:135208
- Language:
- English
- Keywords:
- Copyright date:
- 2011
Journal article
Use of methylation patterns to determine expansion of stem cell clones in human colon tissue.
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