Journal article
Use of methylation patterns to determine expansion of stem cell clones in human colon tissue.
- Abstract:
-
BACKGROUND and AIMS: It is a challenge to determine the dynamics of stem cells within human epithelial tissues such as colonic crypts. By tracking methylation patterns of nonexpressed genes, we have been able to determine how rapidly individual stem cells became dominant within a human colonic crypt. We also analyzed methylation patterns to study clonal expansion of entire crypts via crypt fission. METHODS: Colonic mucosa was obtained from 9 patients who received surgery for colorectal cancer...
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- Publication status:
- Published
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- Publisher copy:
- 10.1053/j.gastro.2010.12.036
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Bibliographic Details
- Journal:
- Gastroenterology
- Volume:
- 140
- Issue:
- 4
- Pages:
- 1241-1250.e1-9
- Publication date:
- 2011-04-01
- DOI:
- EISSN:
-
1528-0012
- ISSN:
-
0016-5085
- Source identifiers:
-
135208
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:135208
- UUID:
-
uuid:e4db6283-8d84-4fcc-9c3b-dde833e8d8f3
- Local pid:
- pubs:135208
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 2011
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