Journal article icon

Journal article

Use of methylation patterns to determine expansion of stem cell clones in human colon tissue.

Abstract:

BACKGROUND and AIMS: It is a challenge to determine the dynamics of stem cells within human epithelial tissues such as colonic crypts. By tracking methylation patterns of nonexpressed genes, we have been able to determine how rapidly individual stem cells became dominant within a human colonic crypt. We also analyzed methylation patterns to study clonal expansion of entire crypts via crypt fission. METHODS: Colonic mucosa was obtained from 9 patients who received surgery for colorectal cancer...

Expand abstract
Publication status:
Published

Actions


Access Document


Authors


Expand authors...
Journal:
Gastroenterology
Volume:
140
Issue:
4
Pages:
1241-1250.e1-9
Publication date:
2011-04-05
DOI:
EISSN:
1528-0012
ISSN:
0016-5085
URN:
uuid:e4db6283-8d84-4fcc-9c3b-dde833e8d8f3
Source identifiers:
135208
Local pid:
pubs:135208

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP