Journal article icon

Journal article

Mast cell tetrahydrobiopterin contributes to itch in mice

Abstract:

GTP cyclohydrolase (GCH1) governs de novo synthesis of the enzyme cofactor, tetrahydrobiopterin (BH4), which is essential for biogenic amine production, bioactive lipid metabolism and redox coupling of nitric oxide synthases. Overproduction of BH4 via upregulation of GCH1 in sensory neurons is associated with nociceptive hypersensitivity in rodents, and neuron‐specific GCH1 deletion normalizes nociception. The translational relevance is revealed by protective polymorphisms of GCH1 in humans, ...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

Actions


Access Document


Files:
Publisher copy:
10.1111/jcmm.13999

Authors


More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM
Subgroup:
RDM Strategic
Oxford college:
Exeter College
Role:
Author
ORCID:
0000-0002-1043-4342
Expand authors...
More from this funder
Grant:
CRC1039 A03
ITCRC1039 Z01
SFB815 A12
Else Kröner Fresenius foundation More from this funder
Publisher:
Wiley Publisher's website
Journal:
Journal of Cellular and Molecular Medicine Journal website
Volume:
23
Issue:
2
Pages:
985-1000
Publication date:
2018-11-18
Acceptance date:
2018-10-13
DOI:
EISSN:
1582-4934
ISSN:
1582-1838
Pubs id:
pubs:948289
URN:
uri:e4d7e507-2538-4efe-a4e3-53b777e8f63b
UUID:
uuid:e4d7e507-2538-4efe-a4e3-53b777e8f63b
Local pid:
pubs:948289

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP