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Chemistry-based functional proteomics: mechanism-based activity-profiling tools for ubiquitin and ubiquitin-like specific proteases.

Abstract:

Determining the biological function of newly discovered gene products requires the development of novel functional approaches. To facilitate this task, recent developments in proteomics include small molecular probes that target proteolytic enzyme families including serine, threonine, and cysteine proteases. For the families of ubiquitin (Ub) and ubiquitin-like (UBL)-specific proteases, such tools were lacking until recently. Here, we review the advances made in the development of protein-bas...

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Publisher copy:
10.1021/pr0341080

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Obstetrics and Gynaecology
Galardy, PJ More by this author
Borodovsky, A More by this author
Kessler, BM More by this author
Ploegh, HL More by this author
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Journal:
Journal of proteome research
Volume:
3
Issue:
2
Pages:
268-276
Publication date:
2004
DOI:
EISSN:
1535-3907
ISSN:
1535-3893
URN:
uuid:e4d0498a-45bd-46c3-bd11-e6b2cca59799
Source identifiers:
8022
Local pid:
pubs:8022

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