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Bactericidal immunity to salmonella in Africans and mechanisms causing its failure in HIV infection

Abstract:

Nontyphoidal strains of Salmonella are a leading cause of death among HIV-infected Africans. Antibody-induced complement-mediated killing protects healthy Africans against Salmonella, but increased levels of anti-lipopolysaccharide (LPS) antibodies in some HIV-infected African adults block this killing. The objective was to understand how these high levels of anti-LPS antibodies interfere with the killing of Salmonella.Sera and affinity-purified antibodies from African HIV-infected adults tha...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pntd.0004604

Authors


O'Shaughnessy, CM More by this author
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Funding agency for:
MacLennan, CA
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Funding agency for:
MacLennan, CA
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS neglected tropical diseases Journal website
Volume:
10
Issue:
4
Pages:
e0004604
Publication date:
2016-04-18
DOI:
EISSN:
1935-2735
ISSN:
1935-2727
URN:
uuid:e4cf688d-64c8-47c0-ad8e-9066017e96b8
Source identifiers:
616816
Local pid:
pubs:616816

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