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A molecular epidemiological study of var gene diversity to characterize the reservoir of Plasmodium falciparum in humans in Africa

Abstract:

BACKGROUND: The reservoir of Plasmodium infection in humans has traditionally been defined by blood slide positivity. This study was designed to characterize the local reservoir of infection in relation to the diverse var genes that encode the major surface antigen of Plasmodium falciparum blood stages and underlie the parasite's ability to establish chronic infection and transmit from human to mosquito. METHODOLOGY/PRINCIPAL FINDINGS: We investigated the molecular epidemiology of the var mul...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1371/journal.pone.0016629

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Publisher:
Public Library of Science Publisher's website
Journal:
PLoS ONE Journal website
Volume:
6
Issue:
2
Pages:
e16629
Publication date:
2011-02-09
Acceptance date:
2011-01-06
DOI:
EISSN:
1932-6203
URN:
uuid:e4cb7815-e2d1-47dc-9fec-fa54e32cf295
Source identifiers:
120372
Local pid:
pubs:120372

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