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Journal article : Review

Recent advances in the biology of tumour hypoxia with relevance to diagnostic practice and tissue‐based research

Abstract:

In this review article, we examine the importance of low levels of oxygen (hypoxia) in cancer biology. We provide a brief description of how mammalian cells sense oxygen. The hypoxia-inducible factor (HIF) pathway is currently the best characterised oxygen sensing system, but recent work has revealed that mammals also use an oxygen-sensing system found in plants to regulate the abundance of some proteins and peptides with an amino-terminal cysteine residue. We discuss how the HIF pathway is a...

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Publication status:
Published
Peer review status:
Peer reviewed

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Files:
Publisher copy:
10.1002/path.5402

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Role:
Author
ORCID:
0000-0002-7750-3242
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Role:
Author
Publisher:
Wiley Publisher's website
Journal:
Journal of Pathology Journal website
Volume:
250
Issue:
2020
Pages:
593-611
Publication date:
2020-03-18
Acceptance date:
2020-02-18
DOI:
EISSN:
1096-9896
ISSN:
0022-3417
Pmid:
32086807
Language:
English
Keywords:
Subtype:
Review
Pubs id:
1090409
Local pid:
pubs:1090409
Deposit date:
2020-03-17

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