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Journal article

Promoter methylation correlates with reduced Smad4 expression in advanced prostate cancer.

Abstract:

BACKGROUND: Transforming growth factor-beta (TGF-beta) is a potent growth inhibitor in a wide range of cell types. A transducer of TGF-beta signaling known as Mothers against decapentaplegic homologue 4 (Smad4) is a known tumor suppressor found on chromosome 18q21.1 and is typically inactivated by deletion or mutation in pancreatic and colorectal cancers. The purpose of the article is to investigate Smad4 expression, gene copy number and methylation status in advanced cases of prostate cancer...

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Publication status:
Published

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Publisher copy:
10.1002/pros.20730

Authors


Aitchison, AA More by this author
Veerakumarasivam, A More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Surgical Sciences, Biomedical Research Centre
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Journal:
The Prostate
Volume:
68
Issue:
6
Pages:
661-674
Publication date:
2008-05-05
DOI:
EISSN:
1097-0045
ISSN:
0270-4137
URN:
uuid:e4c5d834-2c2d-4834-a406-9ca8a77f9c19
Source identifiers:
120610
Local pid:
pubs:120610

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